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Volume 7 ~ Issue 2 (February 2017)


Research Article  open access
Effects of Solid Contents and Various Additives in Drilling Fluids
Rajesh Kanna|| Nandhu M|| Jossy Joy|| Sreekuttan Vijayan|| Johnest P C
India
Research Inventy: International Journal of Engineering & Science , Volume 7 ~ Issue 2 (February 2017)

Paper Index :: : 07.4721/xxxxxxx

Abstract

The project is done to study about the effects of solid contents and various additives in drilling fluids. The objectives of this project work were to determine the Viscosity & Density of Mud Additive (Barite BASO4 specific gravity :4.10 ~ 4.20), while STPP(sodium tri-polyphosphate Na5P3O10) is Viscosifier.The scope of this project is limited to Water based muds only.

KEY WORD: Bentonite, mud weight, mud viscosity, olefins, synthetic paraffins


Research Article  open access
Screening of Natural Compounds as Matrix Metalloproteinase and Aldose Reductase Inhibitors: Drug Design for Diabetic Retinopathy
M.Syed Ali Fathima || R.V.Ramalakshmi || A.Santhanalakshmi || Sonagunalan
India
Research Inventy: International Journal of Engineering & Science , Volume 7 ~ Issue 2 (February 2017)

Paper Index :: : 07.4721/xxxxxxx

Abstract

Diabetic retinopathy (DR) is a micro-vascular complication of diabetes and one of the leading causes of blindness. Two of the possible candidate PROTEINS contributing to the development of diabetic retinopathy are aldose reductase (AR) and Matrix metalloproteinase-2 (MMP2). In the current study plant derived medicinal compounds and chemical compounds are studied by Docking analysis that are carried out using Maestro (10.2) (Schrodinger suite).The screened compounds were found to possess good binding affinity with these proteins and hence are considered diabetic retinopathy inhibitors. In this study, Calebin, Isolated from curcuminoid Plant of turmeric (Curcuma longa) was found to have high Binding Affinity and was proved to be the naturally available novel inhibitor of Aldose reductase. Acarbose was found to have high Binding Affinity to the Matrix metalloproteinase-2 drug target.From this study it is concluded that these natural compounds were found to have good binding affinity with these target proteins and considered to be effective drug targets for treatment of diabetic retinopathy (DR).

KEY WORD: Diabetic retinopathy, Aldose reductase, Matrix metalloproteinase, Schrodinger, Calebin, Acarbose..










































































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